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Make a donation to help fight sarcomas
Sarcomas are rare but aggressive cancers for which there has been little therapeutic progress over the past 30 years. Sarcomas can affect people of all ages, including children and young adults.
Through your donations, you can play an active role in driving innovation and accelerating research that directly benefits patients!
Innovating to Improve Sarcoma Treatment: Four Flagship Research Programs at Gustave Roussy:
Researching and developing new targeted therapies: Today, targeted therapies are ineffective against the majority of sarcoma subtypes, particularly a subtype known as small round cell desmoplastic tumors. This research area aims to understand the biology of these tumors and identify new therapeutic strategies in order to develop new clinical trials for patients whose current treatments have failed.
Gaining a Better Understanding of Tumor Biology: This research area aims to study each tumor cell using new single-cell sequencing technologies. These techniques make it possible to individually characterize 5,000 cells within the tumor, much like studying each piece of a mosaic in detail rather than simply looking at the artwork as a whole. The goal of this research area is to identify the signaling pathways involved in tumor proliferation, non-tumor cell populations (which also play an important role), and potentially the stem cells responsible for treatment resistance and relapse.
Development of new preclinical research models: A limitation in the study of desmoplastic tumors is the lack of models (mice or cells) that can be used in the laboratory. This research area therefore aims to develop new models by surgically harvesting fresh tumor samples from patients undergoing surgery, which will then be transplanted into mice.
Launch of a one-day diagnostic clinic: The goal of this research area is to establish a dedicated clinic so that every patient can receive, within a single day, a consultation combined with a tumor biopsy, which will then be analyzed at the molecular level to enable an accurate diagnosis and a personalized treatment strategy.