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Exposome, Heredity, Cancer, and Health
- Thematic(s)
- Data & AI, Epigenetics, Genetics / Genomics, Public Health & Epidemiology
- Manager(s)
- Gianluca Severi
- Institutional connection
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Gustave Roussy, Inserm, Paris-Saclay University, UVSQ
Summary
The team is studying how the individual factors that make up the exposome, the living environment, and genetic predisposition interact to influence the onset and progression of common chronic diseases: cancers, cardiometabolic diseases, and age-related neurodegenerative diseases. The goal is to assess combined exposure to multiple risk factors, to study their relationship to the onset of diseases throughout the lifespan, and to examine their influence on the progression of these diseases. The team studies the effect of the exposome across generations and the transmission of characteristics among individuals within the same family and across multiple generations.
The team’s work focuses on the following research areas:
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The role of biological and molecular factors in the development of cancers and major chronic diseases.
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The identification of new biomarkers for prediction and early diagnosis.
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The links between lifestyle factors, health behaviors, and chronic diseases.
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Environmental and occupational exposures and their effects on health, as well as their associations with various diseases.
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The determinants and consequences of motor decline during normal and pathological aging.
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Survival and quality of life following the onset of chronic diseases.
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Heredity and the intergenerational transmission of health determinants.
Our research program is based primarily on the E3N-Générations prospective family cohort (www.e3n-generations.fr), but also on case-control studies, research projects, and other health databases. This primarily concerns breast cancer (CECILE, BCAC), prostate cancer (EPICAP, CHLOECAPA, PRACTICAL), lung cancer (WELCA, ICARE), thyroid cancer (CATHY, New Caledonia, EPITHYR), Parkinson’s disease (COURAGE-PD), and the health effects of air pollution (ELAPSE).
The team’s main findings focus on:
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Hormone therapies and the risk of breast, ovarian, endometrial, and skin cancers.
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Intake of fiber, meat, fish, and calcium and the risk of colorectal cancer.
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The ingestion of excipients via medications and cancer risk.
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Environmental exposures and the risks of major chronic diseases.
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The influence of reproductive factors, exogenous hormone use, and physical activity on the risk of Parkinson’s disease.
The main results of the E3N-Generations Cohort are available on the website https://www.e3n-generations.fr/les-resultats
Team members
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SEVERI, Gianluca - Team Leader
Director of Research and Equivalents, Inserm
ALLOU, Isabelle
Engineering Assistant or equivalent, Paris-Saclay University
ALYANAKIAN Mariam
Engineering Assistant or equivalent, Paris-Saclay University
AMIOT Aurelien
University Professors and Hospital Practitioners, Paris-Saclay University
Fanny Artaud
Research Engineer or equivalent, Paris-Saclay University
Yazdan Asgari
Research Engineer or Equivalent, Inserm
Laura BAGLIETTO
Professor, University of Pisa
BAJAWI Ghizlane
Research Engineer or equivalent, Gustave Roussy
BARDE François
Ph.D. Candidate, Paris-Saclay University
BERTRAND Anais
Other status, including apprentice, AP-HP
Caroline Besson
University Professors and Hospital Practitioners, University of Versailles St. Quentin
Régine Billmann
Design Engineer or equivalent, Gustave Roussy
Lea BOUTEILLE
Ph.D. Candidate, Inserm
CABRERA, Leila
Research Engineer or equivalent, Inserm
CADEAU Claire
Research Associate or equivalent, Paris-Saclay University
CERVENKA Iris
Research Engineer or equivalent, Paris-Saclay University
CHAIT Rafika
Design Engineer or equivalent, Gustave Roussy
CHARADA Yasmine
Ph.D. student, Paris-Saclay University
Emilie CORDINA-DUVERGER
Research Engineer or equivalent, Inserm
Emmanuelle CORREIA
Research Engineer or equivalent, Gustave Roussy
Thibaud DE FILIPPIS
Research Engineer or equivalent, Université Paris-Saclay
Soheib DJAMAA
Postdoctoral Researcher, Inserm
DU CHEYRON Joseph
Research Engineer or equivalent, Paris-Saclay University
ELBAZ Alexis
Research Director or equivalent, Inserm
Douae El Fatouhi
Research Engineer or equivalent, Paris-Saclay University
Mélody Enguix
Research Engineer or equivalent, Gustave Roussy
Elodie Faure
Research Engineer or equivalent, Gustave Roussy
Agnès FOURNIER
Research Engineer or equivalent, Inserm
Amandine Gelot
Design Engineer or equivalent, Gustave Roussy
Roselyn GOMES
Research Engineer or equivalent, Gustave Roussy
Pascal Guenel
Emeritus Research Director, Inserm
GUEYE Youssouf
Ph.D. Candidate, Paris-Saclay University
Mariem Hajji
Postdoctoral Researcher, Gustave Roussy
Sofiane Harizi
Research Engineer or equivalent, Paris-Saclay University
HOANG Hong-Minh
Research Engineer or equivalent, Paris-Saclay University
HOANG Lyan
Research Engineer or equivalent, Gustave Roussy
JABER Eva
Research Engineer or equivalent, Inserm
KABORE Rahime
Research Engineer or equivalent, Paris-Saclay University
KARIMI Mojgan
Research Engineer or equivalent, Inserm
Véra Kimmerling
Ph.D. student, Paris-Saclay University
Camille LAPLANCHE
Research Engineer or equivalent, Paris-Saclay University
LEE Pei-Chen
Research Associate or equivalent, National Taipei University of Nursing and Health Sciences
Jonas LEFEVRE-DAUMAL
Research Engineer or equivalent, Paris-Saclay University
LEQUY-FLAHAULT Emeline
Research Fellow and Equivalents, Inserm
LHOMME, Anne
Design Engineer or equivalent, Paris-Saclay University
Safa MADDOURI
Research Engineer or equivalent, Paris-Saclay University
MANCINI Francesca Romana
Research Associate or equivalent, Inserm
Chloé MARQUES
Postdoctoral Fellow, Inserm
MATRAT Mireille
University Lecturer and Hospital Physician, UNIVERSITY OF PARIS-EST CRÉTEIL
MENEGAUX Florence
Research Director and Equivalents, Inserm
MEYER Antoine
University Lecturer and Hospital Practitioner, Paris-Saclay University
Fatima Mohamed
Research Engineer or equivalent, Gustave Roussy
Sadya NAJOO
Ph.D. Candidate, Paris-Saclay University
NAKKACHE Dorra
Research Engineer or equivalent, Paris-Saclay University
Cheikh Tidiane NDOYE
Research Engineer or equivalent, Gustave Roussy
OLIVIER Eléa
Ph.D. Candidate, Paris-Saclay University
PARK See Hyun
Postdoctoral researcher, Gustave Roussy
PAUNESCU Alexandra-Cristina
Research Engineer or equivalent, Gustave Roussy
PERDUCA Vittorio
Associate Professor, UNIVERSITY OF PARIS
Claire Perrin
Research Engineer or equivalent, Paris-Saclay University
Orly Petipa NGA
Ph.D. Candidate, UNIVERSITY OF PARIS 7 - DIDEROT
Denis-Louis PIERRE
Research Engineer or equivalent, Gustave Roussy
PIOT Irwin
Design Engineer or equivalent, Paris-Saclay University
RADOI Lorédana
University Professors and Hospital Practitioners, UNIVERSITY OF PARIS
REN Xuan
Postdoctoral Fellow, Inserm
SENINA Nadège
Engineering Assistant or Equivalent, Paris-Saclay University
SHEIKH Mahdi
Research Fellow and equivalent positions, INTERNATIONAL AGENCY FOR RESEARCH ON CANCER
SPEYER Elodie
Research engineer or equivalent, Paris-Saclay University
SUGIER Pierre-Emmanuel
Associate Professor, UNIVERSITY OF PARIS
Mathilde TISSANDIER
Ph.D. Candidate, UNIVERSITY OF PARIS-EST CRÉTEIL
TOURE Mamadou Idrissa
Design Engineer or equivalent, University of Paris-Saclay
TRUONG Thérèse
Research Associate or equivalent, Inserm
Key publications
Other scientific productions
Contacts
