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Cell Reprogramming, Immunity, and Innovative Biotherapies
- Thematic(s)
- Immuno-oncology, Innovative Therapies, Cell Dynamics
- Attachment unit
- U1363 - Innovative Biotherapies (BioInnov)
- Manager(s)
- Nathalie Chaput, Jean-Luc Perfettini
- Institutional connection
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Gustave Roussy, Inserm, Paris-Saclay University
Summary
Led by Dr. Jean-Luc PERFETTINI and Prof. Nathalie CHAPUT, the team studies the mechanisms by which tumors evade the immune system and the processes underlying resistance to immunotherapies in aggressive and refractory cancers. The team’s approach focuses on the biological and immune mechanisms underlying tumor resistance. The research aims to identify new biomarkers predictive of therapeutic response, to decipher the interactions between tumor cells and immune cells, and to discover new biological targets that will enable the development of innovative biotherapies. The team is developing integrated approaches combining cell biology, tumor immunology, cell therapy, and synthetic biology to better understand tumor plasticity and the immune system’s response to cancer, as well as the mechanisms of cellular reprogramming that lead to the regression of solid cancers and pediatric tumors. Dr. Jean-Luc PERFETTINI’s work focuses more specifically on the mechanisms of cell death, plasticity, and associated cellular reprogramming that can lead to cancer regression. Professor Nathalie CHAPUT’s research is centered on translational tumor immunology and immune biomarkers of response to or resistance against current immunotherapies. The overall goal of this team’s work is to develop new immunotherapy strategies in oncology. Finally, the team is fostering strong collaborations with academic and industrial partners, particularly as part of the MONO-CHEM project funded by the PEPR “Innovative Biotherapies” under the France 2030 program, and actively contributes to advancing translational research and fostering the emergence of startups stemming from its work, such as Signadori Bio.
Team members
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Jean-Luc PERFETTINI - Unit Director
Research Director and Equivalents, Inserm, Gustave Roussy
CHAPUT Nathalie - Assistant Unit Director
University Professors and Hospital Practitioners, Paris-Saclay University, Gustave Roussy
Laurence Albiges
University Professors and Hospital Practitioners, Paris-Saclay University, Gustave Roussy
Awatef Allouch
Research Fellows and Equivalents, Gustave Roussy
ARBAB Ahmadreza
Hospital Physician, Gustave Roussy
BADEL Séverine
Research Technician or equivalent, Gustave Roussy
BESSE Benjamin
University Professors and Hospital Physicians, Paris-Saclay University, Gustave Roussy
Sophie BROUTIN
Hospital Physician, Gustave Roussy
Hugo BRUANT
Postdoctoral Fellow, Gustave Roussy
Filippe CARMO
Postdoctoral Fellow, Gustave Roussy
Lydie Cassard
Research Engineer or equivalent, Gustave Roussy
CASTILLA-LLORENTE Cristina
Hospital Physician, Gustave Roussy
Julia DELAHOUSSE
Hospital Physician, Gustave Roussy
Anne DUPRESSOIR
Research Associate and Equivalents, Inserm
Ronan FLIPPOT
Hospital Physician, Gustave Roussy
GHEZ David
Hospital Physician, Gustave Roussy
Antoine HOLLEBECQUE
Hospital Physician, Gustave Roussy
JOUNIAUX Jean
Design Engineer or equivalent, Gustave Roussy
KERROUCH Elias
Research Technician or equivalent, Gustave Roussy
MIKHAILOVA Anastassia
Postdoctoral Fellow, Inserm
MOSTEFA-KARA Ali
Research Engineer or equivalent, Gustave Roussy
NAIGEON Marie
University Lecturer and Hospital Practitioner, Paris-Saclay University, Gustave Roussy
NOMAN Zaeem
Postdoctoral Fellow, Gustave Roussy
PACI Angelo
University Professors and Hospital Physicians, Paris-Saclay University, Gustave Roussy
PAVLOVA Tatiana
Research Assistants and Technical Staff, Administrative Assistants and Staff, Gustave Roussy
SUN Kevin
Research Technician or Equivalent, Gustave Roussy
ZIMMERMAN Lea
Postdoctoral Fellow, Inserm
Key publications
Other scientific productions
Contacts
